Phenoxybenzamine hydrochloride - CAS 63-92-3

Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.

CaMK, Adrenergic Receptor

Neuroscience, GPCR/G Protein

-32

>99.99%

C18H23Cl2NO

340.3

Cl.CC(COc1ccccc1)N(CCCl)Cc1ccccc1

-20°C

Ice Packs

Small Compound