Phenylbutazone-d9 - CAS 1189479-75-1

Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 μM in the presence of hydrogen peroxide) . It also inhibits prostaglandin I synthase (IC50 = ~25 μM in the presence of hydrogen peroxide) . Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis. Formulations containing phenylbutazone have been used in the treatment of lameness in horses.

COX

Neuroscience, Immunology/Inflammation

1189403

C19H11D9N2O2

317.43

O=C1N(N(C(=O)C1C(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])C2=CC=CC=C2)C3=CC=CC=C3

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