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Molfinity

PHGDH-IN-5 - CAS 17402-86-7

PHGDH-IN-5 - CAS 17402-86-7

MF-0147716-01

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Product Details

  • Bioactivity

    Compound B12 (PHGDH-IN-5) acts as a covalent inhibitor of PHGDH, demonstrating an IC50 value of 0.29 μM. It has been shown to inhibit the proliferation of cancer cell lines that overexpress PHGDH and reduce the production of glucose-derived serine in MDA-MB-468 cells [1].

  • Target

    Dehydrogenase

  • Related Pathways

    Metabolism

  • CAS Number

    17402-86-7

  • Molecular Formula

    C8H5NO4S

  • Molecular Weight

    211.2

  • SMILES

    N(=O)(=O)C1=C2C(S(=O)(=O)C=C2)=CC=C1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound