PHOP - CAS 288862-83-9

Fatty acid amide hydrolase (FAAH), an enzyme responsible for the hydrolysis and inactivation of fatty acid amides like anandamide and oleamide, has been identified as a target by the potent FAAH inhibitor PHOP. PHOP demonstrates remarkable inhibitory activity with K_i values as low as 0.094 nM for human FAAH and 0.2 nM for rat FAAH. Additionally, through a proteomics assay focusing on the serine hydrolase enzyme family, to which FAAH belongs, PHOP's selectivity was evaluated, presenting IC_50 values of 1.1 nM against FAAH, 1.4 nM against triacylglycerol hydrolase (TGH), and greater than 100 μM against an uncharacterized hydrolase (KIAA1363) . This specificity profile of PHOP underscores its potential for yielding precise outcomes in studies involving complex biological systems.

Others, FAAH

Metabolism, Neuroscience, Others

288862-83-9

C18H18N2O2

294.354

O=C(CCCCCc1ccccc1)c1nc2ncccc2o1

-20°C

Ice Packs

Small Compound