PI3K/HDAC-IN-3 - CAS 3006905-22-9

PI3K/HDAC-IN-3 (36) acts as a dual inhibitor targeting PI3K and HDAC, exhibiting respective IC50 concentrations of 0.23 nM for PI3Kα and 172 nM for HDAC1. In MV4-11 cells, it inhibits AKT phosphorylation while enhancing H3 acetylation. Furthermore, PI3K/HDAC-IN-3 (36) demonstrates substantial, dose-dependent anticancer effects in an MV4-11 xenograft model [1].

PI3K, HDAC

DNA Damage/DNA Repair, Chromatin/Epigenetic, PI3K/Akt/mTOR signaling

3006905-22-9

C34H34F2N6O5S

676.73

O(CCCCCCC(NC1=C(N)C=CC=C1)=O)C=2C3=C(C=C(C2)C=4C=C(NS(=O)(=O)C5=C(F)C=C(F)C=C5)C(OC)=NC4)C(C)=NC=N3

-20°C

Ice Packs

Small Compound