PI3Kδ/HDAC6-IN-1 - CAS 3075011-99-0

PI3Kδ/HDAC6-IN-1 (Compound 22E) is an orally active dual inhibitor of PI3Kδ and HDAC6, with IC50 values of 2.4 nM and 6.2 nM, respectively. It exhibits potent antiproliferative effects against non-Hodgkin's lymphoma (NHL) cells and demonstrates antitumor activity in vivo without significant toxicity. PI3Kδ/HDAC6-IN-1 induces cell cycle arrest at the G0/G1 phase and triggers apoptosis. Additionally, it inhibits the PI3K/AKT/mTOR signaling pathway and enhances the acetylation levels of α-tubulin and histone H3.

HDAC, ROS, PI3K, Microtubule Associated, Bcl-2 Family, Caspase, Histone Methyltransferase, Apoptosis

Cytoskeletal Signaling, DNA Damage/DNA Repair, Proteases/Proteasome, Apoptosis, Immunology/Inflammation, PI3K/Akt/mTOR signaling, Chromatin/Epigenetic

3074912

C34H38N10O4

650.73

C(C)C=1N(C=2C(N1)=CC=CC2)C3=NC(=C4C(=N3)N(C)C(CN5C(=O)CN(CC6=CC=C(/C=C/C(NO)=O)C=C6)CC5)=N4)N7CCOCC7

-20°C

Ice Packs

Small Compound