PI3Kα-IN-13 - CAS 2955529-67-4

PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines, exhibiting IC50 values of 0.75 μM (MCF-7), 3.79 μM (HCT-116), 13.71 μM (MDA-MB-231), and 9.85 μM (SW620) . This compound also impedes tumor cell colony formation, migration, and invasion [1].

PI3K

PI3K/Akt/mTOR signaling

2955458

C21H19N5O3

389.41

NC1=NC2=CC(C3=CC=4N=C(N5C[C@@]6([C@](C5)(OCCO6)[H])[H])C=NC4C=C3)=CC=C2O1

-20°C

Ice Packs

Small Compound