PI3Kα-IN-22 - CAS 2925030-26-6

PI3Kα-IN-22 (Compound 17) is a potent, selective, and orally active inhibitor targeting the PI3Kα H1047R mutation, exhibiting an IC 50 of 1 nM in the pAKT T47D AlphaLISA assay. It has demonstrated the ability to induce tumor regressions in the HCC1954 tumor model in mice [1].

PI3K

PI3K/Akt/mTOR signaling

2925030-26-6

C24H23F2N5O3

467.47

[C@@H](NC1=C(C(O)=O)C=CC=C1)(C)C=2C=3N(C(=O)C(C#N)=C(N3)N4CCC(F)(F)CC4)C=C(C)C2

-20°C

Ice Packs

Small Compound