PI3K-IN-58 - CAS 3067572-78-2

PI3K-IN-58 (Compound 17f) is an inhibitor of PI3Kα with an IC50 value of 0.039 μM. It shows significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231, and MDA-MB-453 cell lines with IC50 values of 3.48 μM, 1.06 μM, 2.21 μM, and 0.93 μM, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression of anti-apoptotic proteins Bcl-XL and Bcl-2 while upregulating the expression of the pro-apoptotic protein BAX. This compound is applicable for research in cancer targeting through PI3K pathways.

Apoptosis, Bcl-2 Family, PI3K

Apoptosis, PI3K/Akt/mTOR signaling

3067492

C22H22N6O3S

450.51

C(=C/C(NCCO)=O)\C=1SC2=C(N=C(N=C2C1)C3=C4C(=CC=C3)NN=C4)N5CCOCC5

-20°C

Ice Packs

Small Compound