PI3Kγ inhibitor 7 - CAS 2575863-25-9

PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1]. It also exhibits varying inhibitory effects on other PI3K isoforms, with IC50 values of 4768 nM for PI3Kα, 878.1 nM for PI3Kβ, and 355.2 nM for PI3Kδ.

PI3K

PI3K/Akt/mTOR signaling

2575829

C31H25N9O2

555.59

O=C1C=2C(N=C([C@@H](NC(=O)C3=C4N(N=C3N)C=CC=N4)C)N1C5=CC=CC=C5)=CC=CC2C#CC6=CN(N=C6)C7CC7

-20°C

Ice Packs

Small Compound