Pifithrin-β hydrobromide - CAS 511296-88-1

Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM) .

MDM-2/p53, Ferroptosis, p53

Apoptosis

511207

0.9974

C16H17BrN2S

349.29

Br.Cc1ccc(cc1)-c1cn2c3CCCCc3sc2n1

-20°C

Ice Packs

Small Compound