PIK-75 hydrochloride - CAS 372196-77-5

PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.

PI3K, Apoptosis, DNA-PK

PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair, Apoptosis

372114

0.98

C16H14BrN5O4S·HCl

488.74

Cl.CN(N=Cc1cnc2ccc(Br)cn12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O

-20°C

Ice Packs

Small Compound