PIM447 - CAS 1210608-43-7

PIM447 (LGH447) is an oral, selective pan-PIM kinase inhibitor with antitumor and bone-protective effects. It inhibits PIM1, PIM2, and PIM3, induces apoptosis, and decreases the viability, proliferation, and motility of HuH6 and COA67 cells. PIM447 suppresses tumorigenesis in hepatocellular carcinoma and can be used in the study of multiple myeloma.

Pim, Apoptosis

Apoptosis, Chromatin/Epigenetic, JAK/STAT signaling

1210558

0.9897

C24H23F3N4O

440.46

FC1=C(N=C(C(NC=2C(=CC=NC2)[C@@H]3C[C@H](C)C[C@H](N)C3)=O)C=C1)C4=C(F)C=CC=C4F

-20°C

Ice Packs

Small Compound