Pinusolide - CAS 31685-80-0

Pinusolide is a platelet activating factor (PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.

P38 MAPK, Caspase, Apoptosis, Calcium Channel, ERK, Lipoxygenase, AMPK, PAFR, JNK

Chromatin/Epigenetic, Membrane transporter/Ion channel, Metabolism, GPCR/G Protein, MAPK, Apoptosis, Proteases/Proteasome, PI3K/Akt/mTOR signaling

31605

C21H30O4

346.46

COC(=O)[C@@]1(C)CCC[C@]2(C)[C@@H](CCC3=CCOC3=O)C(=C)CC[C@@H]12

-20°C

Ice Packs

Natural Product