Pirodomast - CAS 108310-20-9

Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is weakly or ineffectively antagonistic to guinea pig bronchospasm induced by histamine, methacholine, serotonin, LTC4, or platelet-activating factor. Pirodomast is a potential antiallergic compound. Pirodomast had only weak relaxant activity on guinea pig trachea in vitro. Pirodomast is a potential antiallergic compound that inhibits the protein hydrolyzing activity of trypsin in vitro, prevents antigen-induced immediate and late asthmatic responses in allergic sheep in vivo, and inhibits antigen-induced airway hyperresponsiveness to histamine and carbachol in allergic sheep.

Thrombin, Serine Protease, Leukotriene Receptor

Proteases/Proteasome, GPCR/G Protein

108281

>99.99%

C18H17N3O2

307.35

O=C1N(C=2C(C(=O)C1N3CCCC3)=CC=CN2)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound