Piromelatine - CAS 946846-83-9

Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be used in studies of sleep-promoting, pain-relieving, anti-neurodegenerative, and antidepressant diseases. diseases, and can be used to improve memory deficits associated with chronic mild stress-induced lack of pleasure in rats.

Melatonin Receptor, 5-HT Receptor, P2X Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel

Neuroscience, GPCR/G Protein, Membrane transporter/Ion channel

946754

>99.99%

C17H16N2O4

312.32

COc1ccc2[nH]cc(CCNC(=O)c3cc(=O)cco3)c2c1

-20°C

Ice Packs

Small Compound