PKC-IN-4 - CAS 2636771-29-2

PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), with an IC 50 value of 0.52 μM. In vitro studies show that PKC-IN-4 effectively suppresses NF-κB activity induced by TNF-α and impedes retinal vasculature permeability induced by both VEGF and TNF-α. [1]

Others, PKC

Cytoskeletal Signaling, Chromatin/Epigenetic, Others

2636740

C21H25N5S

379.52

C(N)C1CCN(C2=C3C(SC4=C3CCCC4)=NC(=N2)C=5C=CN=CC5)CC1

-20°C

Ice Packs

Small Compound