Molfinity

PKI-166 hydrochloride - CAS 2230253-82-2

SKU:MF-0109269

$785.35 USD

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Size 10 mg

Product Details

Bioactivity
Potent EGFR-kinase inhibitor (IC50 = 0.7 nM) . Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and orally bioavailable.
Target
EGFR, Others
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Others, JAK/STAT signaling
CAS Number
2230169
Molecular Formula
C20H19ClN4O
Molecular Weight
366.85
SMILES
Cl.C[C@@H](Nc1ncnc2[nH]c(cc12)-c1ccc(O)cc1)c1ccccc1
Storage Temperature
-20°C
Shipping Conditions
Ice Packs
Category
Small Compound