PKI (5-24), amide - CAS 100891-36-9

PKI (5-24), amide (IP20-amide) is a potent inhibitor of cAMP-dependent protein kinase (PKA) with an inhibition constant (K i) of 2.3 nM [1]. This 20-residue peptide mirrors the active segment of the heat-stable inhibitor protein specific to PKA, showcasing significant inhibitory efficacy.

PKA

Tyrosine Kinase/Adaptors

100846

C94H149N33O30

2221.4

[C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC(O)=O)C(N)=O)=O)=O)[C@H](CC)C)=O)C)=O)CC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)=O)CO)=O)C)=O)[C@H](CC)C)=O)NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)[C@@H](C)O)=O)=O)C)=O)CC(O)=O)=O

-20°C

Ice Packs

Peptide