PKSI-527 - CAS 128837-71-8

PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM) . It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively) . PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times.

Others, Serine Protease

Others, Proteases/Proteasome

128758

C25H32ClN3O4

473.99

[C@@H](CC1=CC=CC=C1)(NC(=O)[C@H]2CC[C@H](CN)CC2)C(NC3=CC=C(CC(O)=O)C=C3)=O.Cl

-20°C

Ice Packs

Small Compound