PKUMDL-LC-101-D04 - CAS 2143896-83-5

PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death.

GPX, Glutathione Peroxidase

Oxidation-Reduction, Metabolism

2143808

0.9965

C14H23ClN4O2S2

378.94

Cl.NCCNS(=O)(=O)c1ccc(NC(=S)NC2CCCC2)cc1

-20°C

Ice Packs

Small Compound