PKZ18 - CAS 849658-87-3

PKZ18 is an antibiotic that inhibits bacterial growth with a MIC value of 32-64 μg/mL against most Gram-positive bacteria. It suppresses the in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria, directly reducing T-box transcription readthrough of associated genes. It prevents codon-anticodon pairing necessary for tRNA binding and is less likely to induce resistance.

Antibacterial, Antibiotic

Microbiology/Virology

849568

C22H26N2O3S

398.518

C(NC1=NC(=C(C)S1)C2=CC=C(C(C)C)C=C2)(=O)[C@@H]3[C@H](C(O)=O)[C@@]4(C[C@]3(CC4)[H])[H]

-20°C

Ice Packs

Small Compound