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Molfinity

Plinabulin - CAS 714272-27-2

Plinabulin - CAS 714272-27-2

MF-0019771-01

$34.67 USD
$34.67 USD
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Product Details

  • Bioactivity

    Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells (IC50: 9.8-18 nM) . Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, thereby interrupting equilibrium of microtubule dynamics. This disrupts mitotic spindle assembly leading to cell cycle arrest at M phase and blockage of cell division.

  • Target

    Microtubule Associated

  • Related Pathways

    Cytoskeletal Signaling

  • CAS Number

    714243

  • Purity

    >99.99%

  • Molecular Formula

    C19H20N4O2

  • Molecular Weight

    336.39

  • SMILES

    CC(C)(C)c1[nH]cnc1C=c1[nH]c(=O)c(=Cc2ccccc2)[nH]c1=O

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound