PLK1/BRD4-IN-1 - CAS 2412707-81-2

PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM) that demonstrates significant anti-tumor efficacy in vivo.

Apoptosis, Androgen Receptor, c-Myc, Epigenetic Reader Domain, PLK, Others

Cell Cycle/Checkpoint, Others, Endocrinology/Hormones, Apoptosis, Chromatin/Epigenetic

2412624

C31H43N9O2

573.73

C(N1C=2C(N3C([C@H]1CC)=NN=C3C)=CN=C(NC4=C(OC)C=C(C(NC5CCN(C)CC5)=O)C=C4)N2)C6CCCCC6

-20°C

Ice Packs

Small Compound