PLK1/BRD4-IN-3 - CAS 2251709-91-6

Compound 21, also known as PLK1/BRD4-IN-3, acts as a selective dual inhibitor targeting both bromodomain 4 (BRD4) and polo-like kinase 1 (PLK1) . It effectively inhibits BRD4-BD1, PLK1, and BRDT-BD1, exhibiting IC50 values of 0.059, 0.127, and 0.245 μM, respectively.

PLK, Epigenetic Reader Domain

Cell Cycle/Checkpoint, Chromatin/Epigenetic

2251709-91-6

C31H43N7O3

561.72

C[C@@H]1N(C=2C(=CN=C(NC3=C(OC4CCCC4)C=C(C(NC5CCN(C)CC5)=O)C=C3)N2)N(C)C1=O)C6CCCC6

-20°C

Ice Packs

Small Compound