PLK1-IN-10 - CAS 2991469-21-5

PLK1-IN-10 (Compound 4Bb), an orally active inhibitor of the PLK1 PBD (polo-box domain), inhibits the interaction between PLK1 and the cell division regulator protein 1 (PRC1) and reduces the protein expression of the CDK1-Cyclin B1 complex. Additionally, PLK1-IN-10 interacts with glutathione (GSH), enhancing cellular oxidative stress and promoting cell death [1].

PLK

Cell Cycle/Checkpoint

2991469-21-5

C23H22FN3O4S

455.5

S(NCC1=CC=C(F)C=C1)(=O)(=O)C=2C3=C4C(C(=O)N(CCN(C)C)C(=O)C4=CC=C3)=CC2

-20°C

Ice Packs

Small Compound