PLK1-IN-9 - CAS 893772-67-3

PLK1-IN-9 (Compound M2), a polo-like kinase 1 (PLK1) inhibitor, targets the PLK proteins modified with peptides 1010pT, cdc25c, and PBIP, exhibiting IC50 values of 1.6, 0.8, and 1.4 μM, respectively. This compound effectively inhibits the proliferation of various cancer cell lines including HeLa, HL60, SNU387/499, and HepG2, demonstrating cytotoxic effects and inducing apoptosis. Additionally, PLK1-IN-9 has been shown to suppress tumor growth in a HepG2 xenograft mouse model.

PLK

Cell Cycle/Checkpoint

893772-67-3

C12H7F3N4O2

296.2

O=C1N=C2C(=NC=3C=C(C=CC3N2C)C(F)(F)F)C(=O)N1

-20°C

Ice Packs

Small Compound