PLX-3618 - CAS 2851986-76-8

PLX-3618 is a monovalent direct degrader capable of degrading BRD4 with a DC50 of 12.2 nM. It promotes the polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting the E3 ubiquitin ligase substrate receptor DCAF11. Furthermore, PLX-3618 inhibits the proliferation of various cancer cells and induces apoptosis in AML cells. It also demonstrates anti-tumor activity against AML in mouse models.

Apoptosis, Epigenetic Reader Domain, Molecular Glues

Apoptosis, PROTAC, Chromatin/Epigenetic

2851986-76-8

C32H27N9O2S

601.68

CC=1C2=C(N3C([C@H](CC(N)=O)N=C2C4=CC=C(C=C4)C5=CC(NC(=O)C6=C7N(N=C6)C=CC=N7)=CC=C5)=NN=C3C)SC1C

-20°C

Ice Packs

Small Compound