PLX647 dihydrochloride - CAS 1779796-38-1

PLX647 dihydrochloride is a potent and selective dual inhibitor of FMS and KIT kinases, with IC50 values of 28 nM and 16 nM, respectively. At a concentration of 1 μM, PLX647 dihydrochloride demonstrates superior selectivity against a wide range of 400 kinases, except FLT3 and KDR, where IC50 values are 91 nM and 130 nM, respectively. This orally active compound holds great potential for targeted kinase inhibition.

Others, c-Fms, c-Kit

Others, Tyrosine Kinase/Adaptors

1779757

C21H19Cl2F3N4

455.31

Cl.Cl.FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncccc34)cn2)cc1

-20°C

Ice Packs

Small Compound