PMMB-187 - CAS 2162952-37-4

PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.

STAT

Stem Cells, JAK/STAT signaling

2162911

C27H23BrN2O6S2

615.52

O=C1C=2C(C(=O)C=C1[C@H](OC(CSC=3SC(CC4=CC=C(Br)C=C4)=NN3)=O)CC=C(C)C)=C(O)C=CC2O

-20°C

Ice Packs

Small Compound