PNU-183792 - CAS 282536-25-8

PNU-183792 is a 4-oxo-1,4-dihydroquinoline that acts as an orally active inhibitor of herpesvirus polymerases (HSV polymerases) . It exhibits broad-spectrum antiviral activity, with IC50 values of 0.69 μM for human cytomegalovirus (HCM), 0.37 μM for varicella-zoster virus, and 0.58 μM for herpes simplex virus (HSV) polymerase. PNU-183792 shows no activity against human α, γ, and δ polymerases but inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV), and rat cytomegalovirus (RCMV) .

HSV

Microbiology/Virology

282503

C23H24ClN3O3

425.91

O=C(NCC1=CC=C(Cl)C=C1)C2=CN(C3=CC=C(C=C3C2=O)CN4CCOCC4)C

-20°C

Ice Packs

Small Compound