Poloppin - CAS 683808-78-8

Poloppin is a protein-protein interactions modulator of the mitotic polo-like kinases that acts by targeting mutant KRAS. It works synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells.

Kras, Others, Autophagy, PLK, Ras

Cell Cycle/Checkpoint, Autophagy, Others, MAPK

683722

C20H15BrF3NO2

438.24

OC(=O)CCC1=CC=C(N1C1=C(C=CC=C1)C(F)(F)F)C1=CC=C(Br)C=C1

-20°C

Ice Packs

Small Compound