Pomalidomide 4'-PEG3-azide - CAS 2271036-46-3

Pomalidomide 4'-PEG3-azide is a chemically synthesized E3 ligase ligand-linker conjugate that incorporates the cereblon ligand derived from Pomalidomide, along with a linker. This compound is utilized in the synthesis of iRucaparib-TP3 (Compound 3), an effective PARP1 degrader developed through the PROTAC strategy and derived from Rucaparib.

E3 Ligase Ligand-Linker Conjugate

PROTAC

2270987

0.9872

C21H26N6O7

474.47

[N-]=[N+]=NCCOCCOCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

-20°C

Ice Packs

PROTAC