Pomalidomide-C5-Dovitinib - CAS 2732969-67-2

Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC linking Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity in FLT3-ITD+ acute myeloid leukemia (AML) cells. It promotes ubiquitin-proteasome-dependent degradation of FLT3-ITD and KIT proteins, thereby inhibiting their downstream signaling pathways and presenting research potential in FLT3-ITD+ AML [1].

PDGFR, c-Kit, c-Fms, PROTACs, FLT, Apoptosis, VEGFR, FGFR

Apoptosis, PROTAC, Tyrosine Kinase/Adaptors, Angiogenesis

2732969-67-2

C39H38FN9O6

747.77

O=C1NC=2C=CC=C(F)C2C(N)=C1C3=NC4=CC=C(C=C4N3)N5CCN(C(=O)CCCCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8)CC5

-20°C

Ice Packs

PROTAC