Ponatinib - CAS 943319-70-8

Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor with IC50 values of 0.37 nM (Abl), 1.1 nM (PDGFRα), 1.5 nM (VEGFR2), 2.2 nM (FGFR1), and 5.4 nM (Src) .

PDGFR, c-Kit, Autophagy, FGFR, VEGFR, Bcr-Abl, Src

Cytoskeletal Signaling, Autophagy, Angiogenesis, Tyrosine Kinase/Adaptors

943241

0.9974

C29H27F3N6O

532.56

C(#CC1=CC(C(NC2=CC(C(F)(F)F)=C(CN3CCN(C)CC3)C=C2)=O)=CC=C1C)C=4N5C(=NC4)C=CC=N5

-20°C

Ice Packs

Small Compound