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Ponatinib Hydrochloride - CAS 1114544-31-8

Ponatinib Hydrochloride - CAS 1114544-31-8

MF-0045211-01

$39.15 USD
$39.15 USD
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Product Details

  • Bioactivity

    Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

  • Target

    PDGFR, Autophagy, FGFR, VEGFR, Src, Bcr-Abl

  • Related Pathways

    Tyrosine Kinase/Adaptors, Angiogenesis, Autophagy, Cytoskeletal Signaling

  • CAS Number

    1114505

  • Purity

    >99.99%

  • Molecular Formula

    C29H28ClF3N6O

  • Molecular Weight

    569.02

  • SMILES

    Cl.CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound