Poseltinib - CAS 1353552-97-2

Poseltinib is an orally active, selective, and irreversible inhibitor of Bruton's tyrosine kinase (BTK), with an IC50 value of 1.95 nM. Poseltinib demonstrates 0.3-, 2.3-, and 2.4-fold higher selectivity for BTK over BMX, TEC, and TXK, respectively. Poseltinib covalently binds to cysteine 481 in BTK’s active site, thereby inhibiting BCR-, FcR-, and TLR-mediated signaling pathways.

Others, TLR, BTK

Tyrosine Kinase/Adaptors, Angiogenesis, Others, Immunology/Inflammation

1353453

0.9998

C26H26N6O3

470.52

O=C(C=C)NC=1C=CC=C(OC2=NC(=NC=3C=COC23)NC4=CC=C(C=C4)N5CCN(C)CC5)C1

-20°C

Ice Packs

Small Compound