Potassium 1H-indol-3-yl sulfate - CAS 2642-37-7

Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR), a key regulator of immune-inflammatory conditions. A metabolite of tryptophan derived from dietary protein, it is produced by intestinal bacteria and metabolized in the liver. In chronic kidney disease patients with impaired renal function, it accumulates in serum as a uremic toxin, inducing oxidative stress and accelerating disease progression. At 250 μM, it activates NF-Κb, promoting TGF-β1 and Smad3 expression in rat proximal tubular cells, which is associated with profibrotic activity.

Endogenous Metabolite, AhR

Immunology/Inflammation, Metabolism

2598

>99.99%

C8H6KNO4S

251.3

[K+].[O-]S(=O)(=O)Oc1c[nH]c2ccccc12

-20°C

Ice Packs

Natural Product