Pozanicline - CAS 161417-03-4

Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozanicline selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2 nAChRs (Ki=16 nM) . It shows high selectivity for α6β2 and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM .

AChR

Neuroscience

161417-03-4

C11H16N2O

192.26

O(C[C@@H]1CCCN1)C2=C(C)N=CC=C2

-20°C

Ice Packs

Small Compound