PP487 - CAS 1092787-12-6

PP487 is a dual tyrosine kinase/PI (3) K inhibitor, exhibiting IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].

EGFR, mTOR, c-Met/HGFR, DNA-PK, VEGFR, PI3K, PDGFR, Src, Bcr-Abl

DNA Damage/DNA Repair, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

1092787-12-6

C14H14BrN5O

348.2

NC1=C2C(=NN(C(C)C)C2=NC=N1)C3=CC(O)=C(Br)C=C3

-20°C

Ice Packs

Small Compound