PPADS - CAS 149017-66-3

PPADS is a P2 receptor antagonist with IC50 values of 68 nM (P2X1) and 214 nM (P2X3) . This compound functions as an ATP (nucleotide) analog, competing for binding sites on the P2 receptors with ATP. Additionally, PPADS acts as a reversible competitive antagonist of the NAADP receptor. It is capable of reversing hyperalgesia, and it diminishes the enhanced NO/NOS signaling and IL-1β production in both peripheral and central steps of the nervous system.

149017-66-3

C14H14N3O12PS2

511.38

O=CC1=C(O)C(=NC(N=NC2=CC=C(C=C2S(=O)(=O)O)S(=O)(=O)O)=C1COP(=O)(O)O)C

-20°C

Ice Packs

Small Compound