PPARα/δ agonist 3 - CAS 3050611-33-8

PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.

PPAR

DNA Damage/DNA Repair, Metabolism

3050570

C23H25F3N2O4

450.451

O=C(O)C(OC=1C(=CC(=CC1C)CN2C(=O)N(C3=CC=C(C=C3)C(F)(F)F)CC2)C)(C)C

-20°C

Ice Packs

Small Compound