PPI-2458 - CAS 431077-35-9

PPI-2458 is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class.

Others, Aminopeptidase

Others, Metabolism

431033

C22H36N2O6

424.53

C[C@@]1([C@@]2([C@@]3(CO3)CC[C@@H](OC(N[C@H]([C@@H](C)C)C(N)=O)=O)[C@H]2OC)[H])[C@@H](CC=C(C)C)O1

-20°C

Ice Packs

Small Compound