Pradefovir - CAS 625095-60-5

Pradefovir (Remofovir) is a reverse transcriptase inhibitor potentially for treatment of chronic HBV infection. Pradefovir is also a liver-targeted prodrug of adefovir. After metabolic activation, Pradefovir was converted to PMEA (9- (2-phosphonylmethoxyethyl) adenine) in human liver microsomes with a K (m) of 60 microM, a maximum rate of metabolism of 228 pmol/min/mg protein, and an intrinsic clearance of about 359 ml/min.

HBV, Cytochromes P450

Metabolism, Microbiology/Virology

625030

0.975

C17H19ClN5O4P

423.79

C(COCP1(=O)O[C@@H](CCO1)C2=CC(Cl)=CC=C2)N3C=4C(N=C3)=C(N)N=CN4

-20°C

Ice Packs

Small Compound