(±) -Praeruptorin A - CAS 73069-25-7

1. (±) -Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca (2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca (2+) /calmodulin-CaMKIV-CREB-NFATc1 and/or Ca (2+) /calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.

Interleukin, NF-κB, p38 MAPK, Akt, Calcium Channel

Cytoskeletal Signaling, Metabolism, PI3K/Akt/mTOR signaling, Membrane transporter/Ion channel, MAPK, Immunology/Inflammation, NF-κB

73069-25-7

0.9973

C21H22O7

386.4

C\C=C(\C)C(=O)O[C@@H]1[C@H](OC(C)=O)c2c(OC1(C)C)ccc1ccc(=O)oc21

-20°C

Ice Packs

Natural Product