Pralatrexate - CAS 146464-95-1

Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities.

DHFR, Apoptosis, Antifolate, TAM Receptor

Cell Cycle/Checkpoint, Metabolism, Apoptosis, DNA Damage/DNA Repair, Tyrosine Kinase/Adaptors

146368

0.9959

C23H23N7O5

477.47

Nc1nc(N)c2nc(CC(CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1

-20°C

Ice Packs

Small Compound