Pralatrexate, (R) - - CAS 1320211-70-8

Pralatrexate, (R) - is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylation and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis.

Others

Others

1320133

C23H23N7O5

477.47

NC=1C2=C(N=CC(C[C@@H](CC#C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1

-20°C

Ice Packs

Small Compound