PRC1-IN-1 - CAS 2396639-29-3

PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.

E1/E2/E3 Enzyme

Ubiquitination

2396607

C24H19ClFN3O2

435.878

O=C(O)C=1NC(C=2C=C(F)C=C3NC=CC32)=C(C1C=4C(Cl)=CC=C5NC=CC54)C(C)C

-20°C

Ice Packs

Small Compound