PRDX1-IN-3 - CAS 2566976-46-1

PRDX1-IN-3 (SOMCL-19-048) is a PRDX1 covalent inhibitor with anti-colorectal cancer activity. PRDX1-IN-3 can effectively inhibit the proliferation of colorectal cancer cells and significantly reduce the anti-tumor effect on colorectal cancer nude mice carrying PRDX1 gene knockout. PRDX1-IN-3 can also upregulate downstream genes of the p53 signaling pathway and exert anti-cancer effects.

MDM-2/p53, Reactive Oxygen Species

Immunology/Inflammation, Apoptosis, NF-κB, Metabolism

2566929

C33H46N2O5

550.73

C[C@@]12[C@](C)([C@]3([C@@](C)(CC1)CC[C@](NC(N[C@H](C(OC)=O)C)=O)(C)C3)[H])CC[C@]4(C)C2=CC=C5C4=CC(=O)C(O)=C5C

-20°C

Ice Packs

Small Compound