Prexasertib dimesylate - CAS 1234015-58-7

Prexasertib dimesylate (LY2606368 dimesylate) is a highly selective, ATP-competitive, second-generation inhibitor of checkpoint kinase 1 (CHK1), with a K_i of 0.9 nM and an IC_50 of <1 nM, and also effectively inhibits CHK2 (IC_50 = 8 nM) and RSK1 (IC_50 = 9 nM) . Its mechanism induces double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.

Apoptosis, Chk, Others

Apoptosis, Others, Cell Cycle/Checkpoint

1233950

C20H27N7O8S2

557.6

CS(O)(=O)=O.CS(O)(=O)=O.COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1

-20°C

Ice Packs

Small Compound